On this special episode of the podcast, Emilia Javorsky interviews Sean Ekins about the dangers of AI drug discovery. They talk about how Sean discovered an extremely toxic chemical (VX) by reversing an AI drug discovery algorithm.
Timestamps: 00:00 Introduction 00:46 Sean’s professional journey 03:45 Can computational models replace animal models? 07:24 The risks of AI drug discovery 12:48 Should scientists disclose dangerous discoveries? 19:40 How should scientists handle dual-use technologies? 22:08 Should we open-source potentially dangerous discoveries? 26:20 How do we control autonomous drug creation? 31:36 Surprising chemical discoveries made by black-box AI systems 36:56 How could the dangers of AI drug discovery be mitigated?
Deric Cheng of the Windfall Trust discusses how AGI could transform the social contract, jobs, and inequality, exploring labor displacement, resilient work, new tax and welfare models, and long-term visions for decoupling economic security from employment.
Researcher Oly Sourbut discusses how AI tools might strengthen human reasoning, from fact-checking and scenario planning to honest AI standards and better coordination, and explores how to keep humans central while building trustworthy, society-wide sensemaking.
Technical specialist Nora Ammann of the UK's ARIA discusses how to steer a slow AI takeoff toward resilient, cooperative futures, covering risks from rogue AI and competition to scalable oversight, formal guarantees, secure infrastructure, and AI-supported bargaining.
